Bacterial Growth and Adaptation in Microdroplet Chemostats
نویسندگان
چکیده
منابع مشابه
Bacterial growth and adaptation in microdroplet chemostats.
We describe herein microfluidic technology for manipulating and monitoring continuous growth of populations of bacteria. A system consisting of approximately ten input and output channels controls more than 100 microdroplet chemostats and enables the manipulation of chemical factors in each microchemostat independently over time. Herein, we characterize the dynamics of bacterial populations in ...
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Chemostat refers to a laboratory device used for growing microorganisms in a cultured environment, and has been regarded as an idealization of nature to study competition modeling of mathematical biology. The simple form of chemostat model assumes that the availability of nutrient and its supply rate are both fixed. In addition the tendency of microorganism to adhere to surfaces is neglected by...
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Traditional assumptions in the simple chemostat model include fixed availability of the nutrient and its supply rate, and fast flow rate to avoid wall growth. However, these assumptions become unrealistic when the availability of a nutrient depends on the nutrient consumption rate and input nutrient concentration and when the flow rate is not fast enough. In this paper, we relax these assumptio...
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HE correlation of spontaneous mutation with active growth in cell culture Thas led in the past to a common tacit assumption that division is required for mutation, an assumption exposed by the expression of mutation rates as some function of division. A ready explanation was provided by the error (copy-error) hypothesis which views mutation as an error in gene duplication, and which predicts th...
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Cells of Escherichia coli, tethered to glass by a single flagellum, were subjected to constant flow of a medium containing the attractant alpha-methyl-DL-aspartate. The concentration of this chemical was varied with a programmable mixing apparatus over a range spanning the dissociation constant of the chemoreceptor at rates comparable to those experienced by cells swimming in spatial gradients....
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ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2013
ISSN: 1433-7851
DOI: 10.1002/anie.201301524